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Cellular hyaluronan is associated with a poor prognosis in
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Hyaluronan (HA) is a biocompatible and biodegradable linear polysaccharide which is of interest for tumor targeting through cell surface CD44 receptors. HA binds with high affinity to CD44 receptors, which are overexpressed in many tumors and involved in cancer metastasis. In the present study, we investigated the impact of HA molecular weight (MW), grafting density, and CD44 receptor density


Multifunctional Hyaluronic Acid and Chondroitin Sulfate
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Characterization of CD44-Mediated Cancer Cell Uptake and
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Cells | Free Full-Text | CD44s Assembles Hyaluronan Coat
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Urologic Oncology: Seminars and Original Investigations otto jokelainen
Summary Background The high molecular weight polysaccharide hyaluronan is a major component of the extracellular matrix between the vital cells of human skin epidermis. The levels of hyaluronan, a


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Hyaluronic acid (HA) and chondroitin sulfate (CS) polymers are extensively used for various biomedical applications, such as for tissue engineering, drug delivery, and gene delivery. Although both these biopolymers are known to target cell surface CD44 receptors, their relative cellular targeting properties and immune activation potential have never been evaluated.


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Otto Jokelainen. Sanna M Pasonen-Seppänen. Markku Tammi [ ] Timo K. Nykopp. Purpose Hyaluronan, a major glycosaminoglycan of the extracellular matrix, can act as an oncogenic component of the


Prognostic value of tumour‐infiltrating lymphocytes (TILs
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Hyaluronan, CD44 and versican in epidermal keratinocyte
by Kai Härkönen 1, Sanna Oikari 1, Heikki Kyykallio 1, Janne Capra 1, Sini Hakkola 1, Kirsi Ketola 1, Uma Thanigai Arasu 1, George Daaboul 2, Andrew Malloy 2, Carla Oliveira 3,4,5, Otto Jokelainen 6,7,8, Reijo Sironen 6,7,8, Jaana M. Hartikainen 6,9 and Kirsi Rilla 1,*



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